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Percent Iron Saturation Analysis

Percent Iron Saturation, also known as transferrin saturation, is a blood test that measures the proportion of transferrin that is saturated with iron. It is calculated by dividing the serum iron level by the total iron-binding capacity (TIBC) and then multiplying by 100 to get a percentage. This test provides insight into how much iron is being carried in the bloodstream relative to the amount that could be carried.


Reference Range:

  • Normal Range: Between 15% and 50%.

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Percent Iron Saturation Analysis is a crucial diagnostic tool for evaluating the efficiency of iron transport in the bloodstream, helping to identify conditions like iron deficiency and iron overload. For individuals with low percent iron saturation indicative of deficiency, management may involve oral or intravenous iron supplementation, along with dietary modifications to increase intake of both heme and non-heme iron. In cases of iron overload, therapeutic phlebotomy is employed to reduce excessive iron levels effectively. Regular monitoring of percent iron saturation, alongside serum iron and ferritin levels, is essential to ensure that the management strategies are adequately addressing the iron-related disorders and to adjust treatments as necessary. This comprehensive approach ensures that iron levels are maintained within an optimal range, preventing the complications associated with both iron deficiency and overload.

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